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Male Breast Cancer

Although breast cancer is predominantly a female disease, males are not immune to this cancer. Male breast cancer comprises 1% of all breast cancer diagnosis.

Risk factors for Male Breast Cancer:

  1. Age: The risk increases with increasing age and male breast cancer usually presents in the 6th or the 7th decade of life
  2. Family history of breast cancer/ Inherited gene mutations: The chances of male breast cancer are higher in people with BRCA 2 mutation and a positive family history of breast cancer
  3. Alcohol
  4. Klinefelter’s syndrome: Men with Klinefelter syndrome have small testicles (smaller than usual). Often, they are unable to produce functioning sperm cells, making them infertile. Compared with other men, they have lower levels of androgens (male hormones) and more estrogens (female hormones). For this reason, they often develop gynecomastia (benign enlargement of the male breast), which is also a differential diagnosis of male breast cancer.Patients with this syndrome have a higher incidence of Male Breast Cancer.
  5. Radiation exposure
  6. Exposure to estrogen: Excessive exposure to estrogen increases the chances of male breast cancer.
  7. Liver disease
  8. Obestiy
  9. Testicular problems: Undescended testis, mumps and Klinefelter’s syndrome increases the chances of male breast cancer.

A common differential diagnosis of Male Breast Cancer is Gynecomastia (benign enlargement of the male breast). Gynecomastia usually results from an imbalance between androgen and estrogen production. This is commonly seen in adolescents or in elderly patients because testosterone levels increase during puberty and decrease with age. Besides these causes, many drugs—including steroids, antidepressants, diuretics, and antihypertensive medications—have also been implicated in the development of gynecomastia, although as many as 50% of cases have no known identifiable cause.

Certain risk factors are common to both gynecomastia and carcinoma: breast irradiation, mumps orchitis, and bilateral cryptorchidism (undescended testis), Klinefelter’s syndrome.

Male Breast Cancer

Male Breast Cancer

Gynecomastia

Gynecomastia

Symptoms:

Lack of awareness is the major cause which prevents early diagnosis of this condition in males. Following are the danger signs, which can point towards a male breast cancer:

If you notice any persistent changes to your breasts, you should contact your doctor. Here are some signs to watch for:

  • a lump in the breast
  • nipple pain
  • an inverted nipple
  • nipple discharge (clear or bloody)
  • enlarged lymph nodes under the arm

Diagnosis: 

Diagnosis of male breast cancer is achieved on the same lines as female breast cancer. Patient is usually subjected to an imaging test followed by histo-pathological confirmation of the diagnosis.

Some patients also require extensive work-up to rule out metastasis to other parts of the body.

Management & Prognosis:

Management of male breast cancer is similar to female breast cancer.

By virtue of the proximity between most male breast cancers and the skin and chest wall, extension to or invasion of these structures is more commonly observed than in women but the prognosis of male breast cancer remains the same as female breast cancer.

For more information regarding the management of this condition, click here

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3 thoughts on “Male Breast Cancer

  1. rohan sir..
    nice article sir,thanx for the info..have few theoretical doubts and a small suggestion…

    my doubts being any change in staging/treatment guidelines from female breast cancer..? and i probably remember reading that BRCA1 is almost never associated with male breast cancer but BRCA2,is associated.. is it true sir? and one more doubt sir.. would gynaecomastia be called a risk factor or an associated finding/condition in male breast cancer?? which would be better term…

    and my honest suggestion is sir that u really write well so someday i see a successful and widely popular newsletter/public info journal/or a internet website etc for breast cancer and its awareness from your side.. a trend maybe or a support system for survivors and family etc.. i hope that u amuse this suggestion someday.. 🙂

    • Dear Ashish,

      Thanks for your suggestion. As far as your doubts are concerned:
      – I have clearly written that BRCA 2 is associated with male breast cancer
      – Gynecomastia is not a risk factor for Breast Cancer. Only if the gynecomastia is associated with Klinefelter’s or liver cirrhosis, does it increase the chances of male breast cancer.

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